2023

Detomasi TC, Batka AE, Valastyan JS, Hydorn MA, Craik CS, Bassler BL, Marletta MA. Proteases influence colony aggregation behavior in Vibrio cholerae. J Biol Chem. 2023 Oct 26:105386. doi: 10.1016/j.jbc.2023.105386. Online ahead of print.

Duddy OP, Silpe JE, Fei C, Bassler BL. Natural silencing of quorum-sensing activity protects Vibrio parahaemolyticus from lysis by an Autoinducer-Detecting Phage. PLoS Genet. 2023 Jul 31;19(7):e1010809. doi: 10.1371/journal.pgen.1010809.

Silpe JE, Duddy OP, Johnson GE, Beggs GA, Hussain FA, Forsberg KJ, Bassler BL. Small protein modules dictate prophage fates during polylysogeny. 2023 Jul 26. 620(7974):625-633. doi: 10.1038/s41586-023-06376-y. 

Silpe JE, Duddy OP, Bassler BL. Induction mechanisms and strategies underlying interprophage competition during polylysogeny. PLoS Pathog. 2023 May 18;19(5):e1011363. doi: 10.1371/journal.ppat.1011363. 

2022

Silpe JE, Duddy OP, Bassler BL. Natural and synthetic inhibitors of a phage-encoded quorum-sensing receptor affect phage-host dynamics in mixed bacterial communities. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2217813119. doi: 10.1073/pnas.2217813119.

Qin B, Bassler BL. Quorum-sensing control of matrix protein production drives fractal wrinkling and interfacial localization of Vibrio cholerae pellicles. Nat Commun. 2022 Oct 13;13(1):6063. doi: 10.1038/s41467-022-33816-6.

Mashruwala AA, Qin B, Bassler BL. Quorum-sensing- and type VI secretion-mediated spatiotemporal cell death drives genetic diversity in Vibrio cholerae. Cell. 2022 Sep 15:S0092-8674(22)01125-4. doi: 10.1016/j.cell.2022.09.003.

Prentice JA, Bridges AA, Bassler BL. Synergy between c-di-GMP and Quorum-Sensing Signaling in Vibrio cholerae Biofilm Morphogenesis. J Bacteriol. 2022 Sep 26:e0024922. doi: 10.1128/jb.00249-22. 

Taylor IR, Murray-Nerger LA, Greco TM, Liu D, Cristea IM, Bassler BL. Protein Interaction Networks of Catalytically Active and Catalytically Inactive PqsE in Pseudomonas aeruginosa. mBio. 2022 Sep 8:e0155922. doi: 10.1128/mbio.01559-22. 

Taylor IR, Jeffrey PD, Moustafa DA, Goldberg JB, Bassler BL. The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa. Biochemistry. 2022 Aug 19;61(17):1894–1903. doi: 10.1021/acs.biochem.2c00334.

Bridges AA, Prentice JA, Wingreen NS, Bassler BL. Signal Transduction Network Principles Underlying Bacterial Collective Behaviors. Annu Rev Microbiol. 2022 May 24;76:235–57. doi: 10.1146/annurev-micro-042922-122020. 

Høyland-Kroghsbo NM, Bassler BL. Phage Infection Restores PQS Signaling and Enhances Growth of a Pseudomonas aeruginosa lasI Quorum-Sensing Mutant. J Bacteriol. 2022 Apr 7;204(5):e0055721. doi: 10.1128/jb.00557-21.

Bridges AA, Prentice JA, Fei C, Wingreen NS, Bassler BL. Quantitative input-output dynamics of a c-di-GMP signal transduction cascade in Vibrio cholerae. PLoS Biol. 2022 Mar 18;20(3):e3001585. doi: 10.1371/journal.pbio.3001585.

Eickhoff MJ, Fei C, Cong JP, Bassler BL. LuxT Is a Global Regulator of Low-Cell-Density Behaviors, Including Type III Secretion, Siderophore Production, and Aerolysin Production, in Vibrio harveyi. mBio. 2022 Jan 18;13(1):e0362121. doi: 10.1128/mbio.03621-21. Online ahead of print.

Simanek KA, Taylor IR, Richael EK, Lasek-Nesselquist E, Bassler BL, Paczkowski JE. The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in Pseudomonas aeruginosa. Microbiol. Spectr. 2022 Feb 23;10(1):e0210821. doi: 10.1128/spectrum.02108-21.

2021

Jemielita M, Mashruwala AA, Valastyan JS, Wingreen NS, Bassler BL. Secreted Proteases Control the Timing of Aggregative Community Formation in Vibrio cholerae. mBio. 2021 Dec 21;12(6):e0151821. doi: 10.1128/mBio.01518-21. 

Yang JQ, Sanfilippo JE, Abbasi N, Gitai Z, Bassler BL, Stone HA. Evidence for biosurfactant-induced flow in corners and bacterial spreading in unsaturated porous media. Proc Natl Acad Sci U S A. 2021 Sep 21;118(38):e2111060118. doi: 10.1073/pnas.2111060118.

Duddy OP, Huang X, Silpe JE, Bassler BL. Mechanism underlying the DNA-binding preferences of the Vibrio cholerae and vibriophage VP882 VqmA quorum-sensing receptors. PLoS Genet. 2021 Jul 6;17(7):e1009550. doi: 10.1371/journal.pgen.1009550. 

Qin B, Fei C, Wang B, Stone HA, Wingreen NS, Bassler BL. Hierarchical transitions and fractal wrinkling drive bacterial pellicle morphogenesis. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2023504118. doi: 10.1073/pnas.2023504118.

Bridges AA, Bassler BL. Inverse regulation of Vibrio cholerae biofilm dispersal by polyamine signals. Elife. 2021 Apr 15;10:e65487. doi: 10.7554/eLife.65487. 

Eickhoff MJ, Fei C, Huang X, Bassler BL. LuxT controls specific quorum-sensing-regulated behaviors in Vibrionaceae spp. via repression of qrr1, encoding a small regulatory RNA. PLoS Genet. 2021 Apr 1;17(4):e1009336. doi: 10.1371/journal.pgen.1009336.

Taylor IR, Paczkowski JE, Jeffrey PD, Henke BR, Smith CD, Bassler BL. Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production. ACS Chem Biol. 2021 Apr 16;16(4):740-752. doi: 10.1021/acschembio.1c00049.

Valastyan JS, Kraml CM, Pelczer I, Ferrante T, Bassler BL. (2021) Saccharomyces cerevisiae Requires CFF1 To Produce 4-Hydroxy-5-Methylfuran-3(2H)-One, a Mimic of the Bacterial Quorum-Sensing Autoinducer AI-2. mBio. 2021 Mar 9;12(2):e03303-20. doi: 10.1128/mBio.03303-20.

Wong GCL, Antani JD, Lele P, Chen J, Nan B, Kühn MJ, Persat A, Bru JL, Høyland-Kroghsbo NM, Siryaporn A, Conrad J, Carrara F, Yawata Y, Stocker R, Brun Y, Whitfield G, Lee C, de Anda J, Schmidt WC, Golestanian R, O'Toole GA, Floyd K, Yildiz F, Yang S, Jin F, Toyofuku M, Eberl L, Nobuhiko N, Zacharoff L, El-Naggar MY, Yalcin SE, Malvankar N, Rojas-Andrade MD, Hochbaum A, Yan J, Stone HA, Wingreen NS, Bassler B, Wu Y, Xu H, Drescher K, Dunkel J. (2021) Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation. Phys Biol. 2021 Jan 14. doi: 10.1088/1478-3975/abdc0e. [Online ahead of print]

Duddy OP, Bassler BL. (2021) Quorum sensing across bacterial and viral domains. PLoS Pathog. 2021 Jan 7;17(1):e1009074. doi: 10.1371/journal.ppat.1009074.

2020

Bridges AA, Fei C, Bassler BL. (2020) Identification of signaling pathways, matrix-digestion enzymes, and motility components controlling Vibrio cholerae biofilm dispersal. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32639-32647. doi: 10.1073/pnas.2021166117.

Mashruwala AA, Bassler BL. (2020) The Vibrio cholerae Quorum-Sensing Protein VqmA Integrates Cell Density, Environmental, and Host-Derived Cues into the Control of Virulence. mBio. 2020 Jul 28;11(4):e01572-20. doi: 10.1128/mBio.01572-20.

Qin B, Fei C, Bridges AA, Mashruwala AA, Stone HA, Wingreen NS, Bassler BL. (2020) Cell position fates and collective fountain flow in bacterial biofilms revealed by light-sheet microscopy. Science. 2020 Jul 3;369(6499):71-77. doi: 10.1126/science.abb8501.

Bassler BL. (2020) From Biochemistry to Genetics in a Flash of Light. Genetics. 2020 Jun;215(2):287-289. doi: 10.1534/genetics.120.303285.

Eickhoff MJ, Bassler BL. (2020) Vibrio fischeri siderophore production drives competitive exclusion during dual-species growth. Mol Microbiol. 2020 Aug;114(2):244-261. doi: 10.1111/mmi.14509.

Fei C, Mao S, Yan J, Alert R, Stone HA, Bassler BL, Wingreen NS, Košmrlj A. (2020) Nonuniform growth and surface friction determine bacterial biofilm morphology on soft substrates. Proc Natl Acad Sci U S A. 2020 Mar 19. pii: 201919607. doi: 10.1073/pnas.1919607117.

Silpe JE, Bridges AA, Huang X, Coronado DR, Duddy OP, Bassler BL. (2020) Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip. Cell Host Microbe. 2020 Feb 19. pii: S1931-3128(20)30065-2. doi: 10.1016/j.chom.2020.01.024.

Huang X, Duddy OP, Silpe JE, Paczkowski JE, Cong J, Henke BR, Bassler BL. (2020) Mechanism underlying autoinducer recognition in the Vibrio cholerae DPO-VqmA quorum-sensing pathway. J Biol Chem. 2020 Mar 6;295(10):2916-2931. doi: 10.1074/jbc.RA119.012104. 

Valastyan JS, Tota MR, Taylor IR, Stergioula V, Hone GAB, Smith CD, Henke BR, Carson KG, Bassler BL. (2020) Discovery of PqsE Thioesterase Inhibitors for Pseudomonas aeruginosa using DNA-Encoded Small Molecule Library Screening. ACS Chem Biol. 2020 Feb 21;15(2):446-456. doi: 10.1021/acschembio.9b00905. 

2019

Mukherjee S, Jemielita M, Stergioula V, Tikhonov M, Bassler BL. (2019) Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors. PLoS Biol. 2019 Dec 12;17(12):e3000579. doi: 10.1371/journal.pbio.3000579.

Bridges AA, Bassler BL. (2019) The intragenus and interspecies quorum-sensing autoinducers exert distinct control over Vibrio cholerae biofilm formation and dispersal. PLoS Biol. 2019 Nov 11;17(11):e3000429. doi: 10.1371/journal.pbio.3000429.

Yan J, Bassler BL. (2019) Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms. Cell Host Microbe. 2019 Jul 10;26(1):15-21. doi: 10.1016/j.chom.2019.06.002. 

McCready AR, Paczkowski JE, Cong JP, Bassler BL. (2019) An autoinducer-independent RhlR quorum-sensing receptor enables analysis of RhlR regulation. PLoS Pathog. 2019 Jun 13;15(6):e1007820. doi: 10.1371/journal.ppat.1007820.

Silpe JE, Bassler BL. (2019) Phage-Encoded LuxR-Type Receptors Responsive to Host-Produced Bacterial Quorum-Sensing Autoinducers. MBio. 2019 Apr 9;10(2). pii: e00638-19. doi: 10.1128/mBio.00638-19.

Mukherjee S, Bassler BL. (2019) Bacterial quorum sensing in complex and dynamically changing environments. Nat Rev Microbiol. 2019 Apr 3. doi: 10.1038/s41579-019-0186-5.

Paczkowski JE, McCready AR, Cong JP, Li Z, Jeffrey PD, Smith CD, Henke BR, Hughson FM, Bassler BL. (2019) An autoinducer analog reveals an alternative mode of ligand binding for the LasR quorum-sensing receptor. ACS Chem Biol. 2019 Feb 14. doi: 10.1021/acschembio.8b00971.

Yan J, Fei C, Mao S, Moreau A, Wingreen NS, Košmrlj A, Stone HA, Bassler BL. (2019) Mechanical instability and interfacial energy drive biofilm morphogenesis. Elife. 2019 Mar 8;8. pii: e43920. doi: 10.7554/eLife.43920.

Xie Q, Zhao A, Jeffrey PD, Kim MK, Bassler BL, Stone HA, Novick RP, Muir TW. (2019) Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chem Biol. 2019 Jan 31. pii: S2451-9456(19)30028-5. doi: 10.1016/j.chembiol.2019.01.006. 

2018

Silpe JE, Bassler BL. (2018) A Host-Produced Quorum-Sensing Autoinducer Controls a Phage Lysis-Lysogeny Decision. Cell. 2018 Dec 5. pii: S0092-8674(18)31458-2. doi: 10.1016/j.cell.2018.10.059.

Høyland-Kroghsbo NM, Muñoz KA, Bassler BL. (2018) Temperature, by Controlling Growth Rate, Regulates CRISPR-Cas Activity in Pseudomonas aeruginosa. MBio. 2018 Nov 13;9(6). pii: e02184-18. doi: 10.1128/mBio.02184-18.

Yan J, Moreau A, Khodaparast S, Perazzo A, Feng J, Fei C, Mao S, Mukherjee S, Košmrlj A, Wingreen NS, Bassler BL, Stone HA. (2018) Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling. Adv Mater. 2018 Oct 8:e1804153. doi: 10.1002/adma.201804153.

Beroz F, Yan J, Sabass B, Stone HA, Bassler BL, Wingreen NS, Meir Y. (2018) Verticalization of bacterial biofilms. Nat Phys. 2018 Sep;14(9):954-960. doi: 10.1038/s41567-018-0170-4.

Mukherjee S, Moustafa DA, Stergioula V, Smith CD, Goldberg JB, Bassler BL. (2018) The PqsE and RhlR proteins are an autoinducer synthase-receptor pair that control virulence and biofilm development in Pseudomonas aeruginosa. PNAS. 2018 Sep 17. pii: 201814023. doi: 10.1073/pnas.1814023115.

Eickhoff MJ, Bassler BL. (2018) SnapShot: Bacterial Quorum Sensing. Cell. 2018 Aug 23;174(5):1328-1328.e1. doi: 10.1016/j.cell.2018.08.003.

Yan J, Nadell CD, Stone HA, Wingreen NS, Bassler BL. (2017) Extracellular-matrix-mediated osmotic pressure drives Vibrio cholerae biofilm expansion and cheater exclusion. Nat Commun. 2017 Aug 23;8(1):327. doi: 10.1038/s41467-017-00401-1.

Mukherjee S, Moustafa D, Smith CD, Goldberg JB, Bassler BL. (2017) The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer. PLoS Pathog. 2017 Jul 17;13(7):e1006504. doi: 10.1371/journal.ppat.1006504.

Hurley A, Bassler BL. (2017) Asymmetric regulation of quorum-sensing receptors drives autoinducer-specific gene expression programs in Vibrio cholerae. PLoS Genet. 2017 May 26;13(5):e1006826. doi: 10.1371/journal.pgen.1006826. 

Kim MK, Zhao A, Wang A, Brown ZZ, Muir TW, Stone HA, Bassler BL. (2017) Surface-attached molecules control Staphylococcus aureus quorum sensing and biofilm development. Nat Microbiol. 2017 May 22;2:17080. doi: 10.1038/nmicrobiol.2017.80.

Yan J, Nadell CD, Bassler BL. (2017) Environmental fluctuation governs selection for plasticity in biofilm production. ISME J. Jul;11(7):1569-1577. doi: 10.1038/ismej.2017.33.

Papenfort K, Silpe JE, Schramma KR, Cong JP, Seyedsayamdost MR, Bassler BL. (2017) A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation. Nat Chem Biol. 2017 May;13(5):551-557. doi: 10.1038/nchembio.2336.

Paczkowski JE, Mukherjee S, McCready AR, Cong JP, Aquino CJ, Kim H, Henke BR, Smith CD, Bassler BL. (2017) Flavonoids suppress Pseudomonas aeruginosa virulence through allosteric inhibition of quorum-sensing receptors. J. Biol. Chem. 2017 Mar 10;292(10):4064-4076. doi: 10.1074/jbc.M116.770552.

Høyland-Kroghsbo NM, Paczkowski J, Mukherjee S, Broniewski J, Westra E, Bondy-Denomy J, Bassler BL. (2016) Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system. PNAS. 2016 Nov 14. doi: 10.1073/pnas.1617415113.

Yan J, Sharo AG, Stone HA, Wingreen NS, Bassler BL. (2016) Vibrio cholerae biofilm growth program and architecture revealed by single-cell live imaging. PNAS. 113(36):E5337-43. doi: 10.1073/pnas.1611494113.

Papenfort K, Bassler BL. (2016) Quorum sensing signal-response systems in Gram-negative bacteria. Nature Reviews Microbiology. 14(9):576–588. doi: 10.1038/nrmicro.2016.89.

Boyaci H, Shah T, Hurley A, Kokona B, Li Z, Ventocilla C, Jeffrey PD, Semmelhack MF, Fairman R, Bassler BL, Hughson FM. (2016) Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO. PLoS Biology. 14(5):e1002464. doi: 10.1371/journal.pbio.1002464. 

Ismail AS, Valastyan JS, Bassler BL. (2016) A Host-Produced Autoinducer-2 Mimic Activates Bacterial Quorum Sensing. Cell Host Microbe. pii: S1931-3128(16)30061-0. doi: 10.1016/j.chom.2016.02.020. 

Drescher K, Dunkel J, Nadell CD, van Teeffelen S, Grnja I, Wingreen NS, Stone HA, Bassler BL. (2016) Architectural transitions in Vibrio cholerae biofilms at single-cell resolution. PNAS. 113(14):E2066–E2072. doi: 10.1073/pnas.1601702113 

Even-Tov E, Omer Bendori S, Valastyan J, Ke X, Pollak S, Bareia T, Ben-Zion I, Bassler BL, Eldar A. (2016) Social Evolution Selects for Redundancy in Bacterial Quorum Sensing. PLoS Biol. 14(2):e1002386. doi: 10.1371/journal.pbio.1002386. 

Bagert JD, van Kessel JC, Sweredoski MJ, Feng L, Hess S, Bassler BL, Tirrell DA. (2016) Time-resolved proteomic analysis of quorum sensing in Vibrio harveyi. Chem. Sci. 7(3):1797-1806. doi: 10.1039/C5SC03340C

Kim KM, Ingremeau F, Zhao A, Bassler BL, and Stone H. (2016) Local and global consequences of flow on bacterial quorum sensing. Nature Microbiology. 1(1): 15005-15009. doi:10.1038/nmicrobiol.2015.5 

2015

Rutherford ST, Valastyan JS, Taillefumier T, Wingreen NS, Bassler BL. (2015) Comprehensive analysis reveals how single nucleotides contribute to noncoding RNA function in bacterial quorum sensing. PNAS. 112(44):E6038-47. doi: 10.1073/pnas.1518958112.

Persat A, Nadell CD, Kim MK, Ingremeau F, Siryaporn A, Drescher K, Wingreen NS, Bassler BL, Gitai Z, Stone HA. (2015) The Mechanical World of Bacteria. Cell. 161(5):988-997. doi: 10.1016/j.cell.2015.05.005.

Lu HD, Spiegel AC, Hurley A, Perez LJ, Maisel K, Ensign LM, Hanes J, Bassler BL, Semmelhack MF, Prud'homme RK (2015) Modulating Vibrio cholerae Quorum-Sensing-Controlled Communication Using Autoinducer-Loaded Nanoparticles. Nano Lett. 15(4):2235-41. doi: 10.1021/acs.nanolett.5b00151. 

Papenfort K, Förstner KU, Cong JP, Sharma CM, Bassler BL (2015) Differential RNA-seq of Vibrio cholerae identifies the VqmR small RNA as a regulator of biofilm formation. PNAS. 112(7):E766-75. doi: 10.1073/pnas.1500203112. 

Nadell CD, Drescher K, Wingreen NS, Bassler BL (2015) Extracellular matrix structure governs invasion resistance in bacterial biofilms. ISME J. doi: 10.1038/ismej.2014.246. [Epub ahead of print]

Miller L, O'Loughlin C, Zhang Z, Siryaporn A, Silpe JE, Bassler BL, Semmelhack MF (2015) Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa. J Med Chem. 58(3):1298-306. doi: 10.1021/jm5015082. 

Feng L, Rutherford ST, Papenfort K, Bagert JD, van Kessel JC, Tirrell DA, Wingreen NS, Bassler BL (2015) A Qrr Noncoding RNA Deploys Four Different Regulatory Mechanisms to Optimize Quorum-Sensing Dynamics. Cell. 160(1-2):228-40. doi: 10.1016/j.cell.2014.11.051.

2014

Ke X, Miller LC, Bassler BL (2014) Determinants governing ligand specificity of the Vibrio harveyi LuxN quorum-sensing receptor. Mol Microbiol. 95(1):127-42. doi: 10.1111/mmi.12852.

van Kessel JC, Rutherford ST, Cong JP, Quinodoz S, Healy J, Bassler BL (2014) Quorum sensing regulates the osmotic stress response in Vibrio harveyi. J Bacteriol. 197(1):73-80. doi: 10.1128/JB.02246-14.

Bassler BL, Wingreen NS (2014) Working together at the interface of physics and biology. Phys Biol. 11(5):053010. doi: 10.1088/1478-3975/11/5/053010.

Schluter J, Nadell CD, Bassler BL, Foster KR (2014) Adhesion as a weapon in microbial competition. ISME J. 9(1):139-49. doi: 10.1038/ismej.

Werner KM, Perez LJ, Ghosh R, Semmelhack MF, Bassler BL (2014) Caenorhabditis elegans recognizes a bacterial quorum-sensing signal molecule through the AWCON neuron. J Biol Chem. 289(38):26566-73. doi: 10.1074/jbc.M114.573832. 

Shao Y, Bassler BL (2014) Quorum regulatory small RNAs repress type VI secretion in Vibrio cholerae. Mol Microbiol. 92(5):921-30. doi: 10.1111/mmi.12599. 

Ke X, Miller LC, Ng WL, Bassler BL (2014) CqsA-CqsS quorum-sensing signal-receptor specificity in Photobacterium angustum. Mol Microbiol. (4):821-33. doi: 10.1111/mmi.12502. 

Drescher K, Nadell CD, Stone HA, Wingreen NS, Bassler BL (2014) Solutions to the public goods dilemma in bacterial biofilms. Curr Biol. 24(1): 50-5. doi: 10.1016/j.cub.2013.10.030. 

Perez LJ, Karagounis TK, Hurley A, Bassler BL, Semmelhack MF (2014) Highly Potent, Chemically Stable Quorum Sensing Agonists for Vibrio Cholerae. Chem Sci. 5(1):151-155.

2013

O'Loughlin CT, Miller LC, Siryaporn A, Drescher K, Semmelhack MF, Bassler BL (2013) A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proc Natl Acad Sci U S A. 110(44):17981-6.  10.1073/pnas.1316981110. Epub 2013 Oct 18.

Shao Y*, Feng L*, Rutherford ST, Papenfort K, and Bassler BL (2013) Functional determinants of the quorum-sensing non-coding RNAs and their roles in target regulation. EMBO J. 32(15):2158-71. doi: 10.1038/emboj.2013.155. Epub 2013 Jul 9.

van Kessel JC, Ulrich LE, Zhulin IB, and Bassler BL (2013) Analysis of Activator and Repressor Functions Reveals the Requirements for Transcriptional Control by LuxR, the Master Regulator of Quorum Sensing in Vibrio harveyi. mBio. 4(4). pii: e00378-13. doi: 10.1128/mBio.00378-13.

Bassler B, Vogel J. (2013) Bacterial regulatory mechanisms: the gene and beyond.  Curr Opin Microbiol. ISSN 1369-5274, 10.1016/j.mib.2013.04.001

Drescher K, Shen Y, Bassler BL, Stone HA. (2013) Biofilm streamers cause catastrophic disruption of flow with consequences for environmental and medical systems. Proc Natl Acad Sci U S A. 110:4345-4350 PMCID:PMC3600445

Nadell CD, Bucci V, Drescher K, Levin SA, Bassler BL, Xavier JB. (2013) Cutting through the complexity of cell collectives. Proc Royal Society. 280 20122770;doi:10. 1098/rspb.2012.2770.

van Kessel JC, Rutherford ST, Shao Y, Utria AF, Bassler BL. (2013) Individual and combined roles of the master regulators AphA and LuxR in control of the Vibrio harveyi quorum-sensing regulon. J Bacteriol195:436-443.

2012

Perez LJ, Ng WL, Marano P, Brook K, Bassler BL, Semmelhack MF (2012) Role of the CAI-1 fatty acid tail in the Vibrio cholerae quorum sensing response.  J Med Chem 55:9669-9681

Rutherford ST, Bassler BL. (2012) Bacterial quorum sensing: its role in virulence and possibilities for its control.  In Cold Spring Harbor Perspectives. Bacterial Pathogens Eds Maloy S and Cossart P. Cold Spring Harbor Press

Ng WL, Perez L, Cong J, Semmelhack MF, Bassler BL. (2012) Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios.  PLoS Pathog Jun; 8(6):e1002767. PMCID: PMC3386246

Bassler BL, (2012) Microbes as Menaces, Mates, and Marvels.  In Daedalus.  Eds. Barenbaum M and Meinwald G.  American Academy of Arts and Sciences Press. Cambridge MA Vol. 141. No 3 pp 67-76

Wei Y, Ng WL, Cong J, Bassler BL (2012) Ligand and antagonist driven regulation of the Vibrio choleraequorum-sensing receptor CqsS. Mol Microbiol  83:1095-1108. PMCID: PMC3310172

Shao Y, Bassler BL (2012) Quorum-sensing non-coding small RNAs use unique pairing regions to differentially control mRNA targets. Mol Microbiol  83: 599-611 PMCID: PMC3262071

2011

Bolitho ME, Perez LJ, Koch MJ, Ng WL, Bassler BL, Semmelhack MF (2011) Small molecule probes of the receptor binding site in the Vibrio cholerae CAI-1 quorum sensing circuit. Bioorg Med Chem. 19(22):6906-18.

Nadell CD and Bassler BL (2011) A fitness trade-off between local competition and dispersal in Vibrio cholerae biofilms. Proc Natl Acad Sci, USA. 108:14181-14185 PMCID: PMC3161532

Wang Y, Tu KC, Ong NP, Bassler BL, and Wingreen NS (2011) Protein level fluctuation correlation at the microcolony level and its application to the Vibrio harveyi quorum-sensing circuit. Biophys J. 100(12):3045-53.

Stauff  DL and BL Bassler (2011) Quorum Sensing in Chromobacterium violaceum: DNA Recognition and Gene Regulation by the CviR Receptor. J Bacteriol 193:3871-3878.

Teng, S-W, Schaffer JN., Tu KC, Mehta, P, Lu W, Ong, NP, Bassler BL, and NS Wingreen (2011) Active regulation of receptor ratios controls Integration of quorum-sensing signals in Vibrio harveyi. Mol Syst Biol 7:491. PMCID: PMC3130561.

Chen G, Swem LR, Swem DL, Stauff DL, O'Loughlin CT, Jeffrey PD, Bassler BL, Hughson FM. (2011) A strategy for antagonizing quorum sensing. Mol Cell 42: 199-209.

Ng WL, Perez LJ, Wei Y, Kraml C, Semmelhack MF, Bassler BL. (2011) Signal production and detection specificity in Vibrio CqsA/CqsS quorum-sensing systems. Mol Microbiol. 79: 1407-1417.

Wei Y, Perez LJ, Ng WL, Semmelhack MF, Bassler BL (2011) Mechanism of Vibrio cholerae autoinducer-1 Biosynthesis. ACS Chem Biol. 6: 356-365.

Rutherford ST, van Kessel JC, Shao Y, Bassler BL (2011) AphA and LuxR/HapR reciprocally control quorum sensing in vibrios. Genes Dev 25: 397-408.

2010

Bassler BL (2010) Cell to Cell Communication. Proc Am Philos Soc 154:307-314

Bassler BL (2010) Small cells--big future. Mol Biol Cell 21: 3786-3787.

Waters CM, Wu JT, Ramsey ME, Harris RC, Bassler BL (2010) Quorum sensing controls type three secretion in Vibrio harveyi through repression of ExsA. Appl Environ Microbiol 76: 4996-5004.

Ng WL, Wei Y, Perez LJ, Cong J, Long T, Koch M, Semmelhack MF, Wingreen NS, Bassler BL. (2010) Probing bacterial transmembrane histidine kinase receptor-ligand interactions with natural and synthetic molecules. Proc Natl Acad Sci. 107: 5575-5580.

Teng SW, Wang Y, Tu KC, Long T, Mehta P, Wingreen NS, Bassler BL, Ong NP. (2010) Measurement of the copy number of the master quorum-sensing regulator of a bacterial cell. Biophys J 98: 2024-2031.

Tu KC, Long T, Svenningsen SL, Wingreen NS, Bassler BL. (2010) Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi quorum-sensing response. Mol Cell 37: 567-579.

 

2009

 

Mehta P, Goyal S, Long T, Bassler BL, Wingreen NS (2009) Information processing and signal integration in bacterial quorum sensing. Mol Syst Biol 5: 325.

Kelly RC, Bolitho ME, Higgins DA, Lu W, Ng WL, Jeffrey PD, Rabinowitz JD, Semmelhack MF, Hughson FM, Bassler BL. (2009) The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat Chem Biol 5: 891-895.

Ng WL, Bassler BL (2009) Bacterial quorum-sensing network architectures. Annu Rev Genetics 43: 197-222.

Swem LR, Swem DL, O'Loughlin CT, Gatmaitan R, Zhao B, Ulrich SM, Bassler BL (2009) A quorum-sensing antagonist targets both membrane-bound and cytoplasmic receptors and controls bacterial pathogenicity. Mol Cell 35: 143-153.

Long T, Tu KC, Wang Y, Mehta P, Ong NP, Bassler BL, Wingreen NS (2009) Quantifying the integration of quorum-sensing signals with single-cell resolution. PLoS Biol 7: e68

Svenningsen SL, Tu KC, Bassler BL (2009) Gene dosage compensation calibrates four regulatory RNAs to control Vibrio cholerae quorum sensing. EMBO J 28: 429-439.

Hammer BK, Bassler BL (2009) Distinct sensory pathways in Vibrio cholerae El Tor and Classical biotypes modulate c-di-GMP levels to control biofilm formation. J Bacteriol 191: 169-177.

Hickson J, Yamada SD, Berger J, Alverdy J, O'Keefe J, Bassler BL and Rinker-Schaeffer C (2009) Societal interaction in ovarian cancer matastasis: a quorum-sensing hypothesis.  Clin Exp Metastasis 26: 67-76

2008

Tu KC, Waters CM, Svenningsen SL, Bassler BL (2008) A small-RNA-mediated negative feedback loop controls quorum-sensing dynamics in Vibrio harveyi. Mol Microbiol 70: 896-907.

Nadell CD, Bassler BL, Levin SA (2008) Observing bacteria through the lens of social evolution. J Biol 7: 27.

Pompeani AJ, Irgon JJ, Berger MF, Bulyk ML, Wingreen NS, Bassler BL (2008) The Vibrio harveyi master quorum-sensing regulator, LuxR, a TetR-type protein is both an activator and a repressor: DNA recognition and binding specificity at target promoters. Mol Microbiol 70: 76-88.

Swem LR, Swem DL, Wingreen NS, Bassler BL (2008) Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi. Cell 134: 461-473.

Waters CM, Lu W, Rabinowitz JD, Bassler BL (2008) Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT. J Bacteriol 190: 2527-2536.

Nackerdien, Keynan ZA, Bassler BL, Lederberg J and Thaler DS (2008) Quorum sensing influences Vibrio harveyi growth rates in a manner not fully accounted for by the marker effect of bioluminescence. PLoS ONE3:1-9. PMCID:PMC2249925.

Hammer BK and Bassler BL (2008) Signal integration in the Vibrio harveyi and Vibrio cholerae quorum sensing circuits.  In: Chemical Communication Among Microbes, eds. Bassler BL and Winans SC, American Society for Microbiology, Washington DC pp 323-332

Winans SC and Bassler BL (Eds) (2008) Chemical Communication Among Bacteria.  American Society for Microbiology, Washington DC

Svenningsen SL, Waters CM, Bassler BL (2008) A negative feedback loop involving small RNAs accelerates Vibrio cholerae's transition out of quorum-sensing mode. Genes Dev 22: 226-238.

2007

2005

Lenz DH, Miller MB, Zhu J, Kulkarni RV and Bassler BL (2005) CsrA and three redunCsrA and three redundant small RNAs regulate quorum sensing in Vibrio cholerae. Mol Microbiol 58: 1186-1202. 

Xavier KB, Bassler BL. (2005) Interference with AI-2-mediated bacterial cell-cell communication. Nature437: 750-753.

Waters CM, Bassler BL. (2005) Quorum sensing: cell-to-cell communication in bacteria. Annu Rev Cell Dev Biol 21: 319-346. 

Neiditch MB, Federle MJ, Miller ST, Bassler BL and Hughson FM (2005) Regulation of LuxPQ receptor activity by the quorum-sensing signal autoinducer-2. Mol Cell 18: 507-518. 

Ulrich DL, Kojetin D, Bassler BL, Cavanagh J, Loria JP. (2005) Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing. J Mol Biol347: 297-307. 

Semmelhack MF, Campagna SR, Federle MJ and Bassler BL (2005) An expeditious synthesis of DPD and boron binding studies. Org Lett 7: 569-572. 

Xavier KB, Bassler BL (2005) Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. J Bacteriol 187: 238-248. 

2004

Ulrich DL, Thompson R, Bassler B, Cavanagh J and Loria JP (2004) 1H, 15N, and 13C chemical shift assignments of the Vibrio harveyi histidine phosphotransferase protein LuxU. J Biomol NMR 29: 551-552. 

Henke JM and Bassler BL (2004) Quorum sensing regulates type III secretion in Vibrio harveyi and Vibrio parahaemolyticus. J Bacteriol 186: 3794-3805. 

Henke JM and Bassler BL (2004) Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi. J Bacteriol 186: 6902-6914. 

Henke JM and Bassler BL (2004) Bacterial social engagements. Trends Cell Biol 14: 648-656. 

Semmelhack MF, Campagna SR, Hwa C, Federle MJ and Bassler BL (2004) Boron binding with the quorum sensing signal AI-2 and analogues. Org Lett 6: 2635-2637. 

Miller ST, Xavier KB, Campagna SR, Taga ME, Semmelhack MF, et al. (2004) Salmonella typhimuriumrecognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. Mol Cell 15: 677-687. 

Lenz DH, Mok KC, Lilley BN, Kulkarni RV, Wingreen NS, et al. (2004) The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell 118: 69-82. 

Henke, JM and BL Bassler (2004) Quorum sensing controls type III secretion in Vibrio harveyi. J. Bacteriol.186:3794 - 3805. PMCID: PMC419960.

2003

Taga ME and Bassler BL (2003) Chemical communication among bacteria. Proc Natl Acad Sci USA 100 Suppl 2: 14549-14554. 

Zhao G, Wan W, Mansouri S, Alfaro JF, Bassler BL, et al. (2003) Chemical synthesis of S-ribosyl-L-homocysteine and activity assay as a LuxS substrate. Bioorg Med Chem Lett 13: 3897-3900. 

Federle MJ and Bassler BL (2003) Interspecies communication in bacteria. J Clin Invest 112: 1291-1299. 

Taga ME, Miller ST and Bassler BL (2003) Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium. Mol Microbiol 50: 1411-1427. 

Hammer BK and Bassler BL (2003) Quorum sensing controls biofilm formation in Vibrio cholerae. Mol Microbiol 50: 101-104. 

Xavier KB and Bassler BL (2003) LuxS quorum sensing: more than just a numbers game. Curr Opin Microbiol 6: 191-197. 

Mok KC, Wingreen NS and Bassler BL (2003) Vibrio harveyi quorum sensing: a coincidence detector for two autoinducers controls gene expression. Embo J 22: 870-881. 

2002

Mok, KC and BL Bassler. (2002) Two - component control of quorum sensing in Gram negative bacteria. In:Histidine Kinases in Signal Transduction , eds. M. Inouye and R. Dutta, Academic Press, London, pp. 313 - 340.

Miller MB, Skorupski K, Lenz DH, Taylor RK and Bassler BL (2002) Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae. Cell 110: 303-314. 

Bassler BL (2002) Small talk. Cell-to-cell communication in bacteria. Cell 109: 421-424. 

Zhu J, Miller MB, Vance RE, Dziejman M, Bassler BL, et al. (2002) Quorum-sensing regulators control virulence gene expression in Vibrio cholerae. Proc Natl Acad Sci USA 99: 3129-3134. 

Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, et al. (2002) Structural identification of a bacterial quorum-sensing signal containing boron. Nature 415: 545-549. 

Winans SC and Bassler BL (2002) Mob psychology. J Bacteriol 184: 873-883. 

2001

Taga ME, Semmelhack JL and Bassler BL (2001) The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Mol Microbiol 42: 777-793. 

Schauder S, Shokat K, Surette MG and Bassler BL (2001) The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule. Mol Microbiol 41: 463-476. 

Schauder S and Bassler BL (2001) The languages of bacteria. Genes Dev 15: 1468-1480. 

Miller MB and Bassler BL (2001) Quorum sensing in bacteria. Annu Rev Microbiol 55: 165-199. 

Bassler, BL (2001) Tiny conspiracies: cell-to-cell communication allows bacteria to coordinate their activity. Natural History Magazine 110:16-22.

Miller, MB and BL Bassler. (2001) Quorum Sensing. In: The Prokaryotes. M. Dworkin (ed) Electronic Format

2000

Joyce EA, Bassler BL and Wright A (2000) Evidence for a signaling system in Helicobacter pylori:detection of a luxS-encoded autoinducer. J Bacteriol 182: 3638-3643. 

Lilley BN and Bassler BL (2000) Regulation of quorum sensing in Vibrio harveyi by LuxO and sigma-54.Mol Microbiol 36: 940-954. 

Freeman JA, Lilley BN and Bassler BL (2000) A genetic analysis of the functions of LuxN: a two-component hybrid sensor kinase that regulates quorum sensing in Vibrio harveyi. Mol Microbiol 35: 139-149. 

1999

Bassler BL (1999) How bacteria talk to each other: regulation of gene expression by quorum sensing.Curr Opin Microbiol 2: 582-587.

Surette MG, Miller MB and Bassler BL (1999) Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Proc Natl Acad Sci USA 96: 1639-1644. 

Freeman JA and Bassler BL (1999) Sequence and function of LuxU: a two-component phosphorelay protein that regulates quorum sensing in Vibrio harveyi. J Bacteriol 181: 899-906.  

Freeman JA and Bassler BL (1999) A genetic analysis of the function of LuxO, a two-component response regulator involved in quorum sensing in Vibrio harveyi. Mol Microbiol 31: 665-677. 

Surette MG and Bassler BL (1999) Regulation of autoinducer production in Salmonella typhimurium.Mol Microbiol 31: 585-595. 

Bassler, BL (1999) A multi - channel two-component signalling relay control s quorum sensing in Vibrio harveyi. In: Bacterial Cell-Cell Signalling , eds. G. Dunny and S. Winans. American Society for Microbiology, Washington, DC p. 259 - 273.

1987-1998

Surette MG and Bassler BL (1998) Quorum sensing in Escherichia coli and Salmonella typhimurium.Proc Natl Acad Sci USA 95: 7046-7050. 

Bassler BL, Greenberg EP and Stevens AM (1997) Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi. J Bacteriol 179: 4043-4045. 

Bassler, BL, and MR Silverman. 1994 Intercellular communication in marine Vibrio: Density-dependent regulation of the expression of bioluminescence. In:Two Component Signal Transduction, eds. J.A. Hoch and T.J. Silhavy, American Society for Microbiology, Washington, DC, pp. 431-445.

Bassler BL, Wright M and Silverman MR (1994) Multiple signalling systems controlling expression of luminescence in Vibrio harveyi: sequence and function of genes encoding a second sensory pathway. Mol Microbiol 13: 273-286. 

Bassler BL, Wright M and Silverman MR (1994) Sequence and function of LuxO, a negative regulator of luminescence in Vibrio harveyi. Mol Microbiol 12: 403-412. 

Bassler BL, Wright M, Showalter RE and Silverman MR (1993) Intercellular signalling in Vibrio harveyi:sequence and function of genes regulating expression of luminescence. Mol Microbiol 9: 773-786. 

Yu C, Bassler BL and Roseman S (1993) Chemotaxis of the marine bacterium Vibrio furnissii to sugars. A potential mechanism for initiating the chitin catabolic cascade. J Biol Chem 268: 9405-9409. 

Bassler BL, Yu C, Lee YC and Roseman S (1991) Chitin utilization by marine bacteria. Degradation and catabolism of chitin oligosaccharides by Vibrio furnissii. J Biol Chem 266: 24276-24286. 

Bassler, B., P. Gibbons, C. Yu, and S. Roseman (1991) Chitin utilization by marine bacteria. Chemotaxis to chitin oligosaccharides by Vibrio furnissii. J Biol Chem 266: 24268-24275. 

Yu, C., A. Lee, B. Bassler, and S. Roseman (1991) Chitin utilization by marine bacteria. A physiological function for bacterial adhesion to immobilized carbohydrates. J Biol Chem 266: 24260-24267. 

Bassler B, Gibbons P and Roseman S (1989) Chemotaxis to chitin oligosaccharides by Vibrio furnissii, a chitinivorous marine bacterium. Biochem Biophys Res Commun 161: 1172-1176. 

Hallenbeck PC, Vimr ER, Yu F, Bassler B and Troy FA (1987) Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-alpha-2,8-sialosyl carbohydrate units. J Biol Chem 262: 3553-3561.